Change 1: Measurability of Tumors at Baseline
  
    
    
      
        | RECIST 1.0:
           
            At baseline, measurable tumor lesions will be categorized as follows:
              
                 Lesions that can be accurately measured in at least one dimension [longest diameter to be recorded] as ≥ 20 mm with conventional techniques or ≥ 10 mm with spiral CT scan | RECIST 1.1:
          
             Tumor lesions: Must be accurately measured in at least one dimension (longest diameter in the plane of measurement is to be recorded) with a minimum size of:
              
                10 mm by CT scan (irrespective of scanner type) and MRI (no less than double the slice thickness and a minimum of 10 mm) 10 mm caliper measurement by clinical exam (when superficial) 20 mm by chest X-ray (if clearly defined and surrounded by aerated lung)  |